Abstract： Objective： To evaluate the efficacy of pricking-bloodletting at Shaoshang （LU11） and Shangyang （LI1） points for postoperative sore throat in patients undergoing general anesthesia with endotracheal intubation. Methods：A total of 110 patients who were admitted to the ICU of the First Affiliated Hospital of Guangzhou University of Chinese Medicine from April 1， 2024， to July 31， 2025， after surgery under general anesthesia with endotracheal intubation were enrolled. They were randomly assigned using a variable block length randomization method into the control group （57 cases） and the pricking-bloodletting group （53 cases）. The control group received conventional treatment， while the pricking-bloodletting group received additional pricking and bloodletting at Shaoshang （LU11） and Shangyang （LI1） points. Scores of postoperative sore throat grade and hoarseness severity were recorded at 0， 2， 6， 12， 24， and 48 hours after extubation， and Kaplan-Meier （KM） curves were plotted. The cumulative consumption of Sufentanil from ICU admission to 48 hours after extubation was calculated， and adverse events during treatment were recorded. Results：At 6，12，24，and 48 hours postoperatively，the postoperative sore throat scores in the pricking-bloodletting group were significantly lower than those in the control group （P＜0.05）. The KM curves and Log-rank test showed a statistically significant difference in the postoperative sore throat relief KM curves between the two groups （P＜0.05）； the pricking-bloodletting group achieved rapid postoperative sore throat relief with stable analgesic effect. The univariate Cox proportional hazards model showed that the time to pain relief was significantly shortened in the pricking-bloodletting group [hazard ratio （HR）=3.09， 95%CI （1.96-4.85）， P＜0.05]. Univariate Cox regression analysis indicated that age，American Society of Anesthesiologists （ASA） class，and other included factors did not affect postoperative sore throat relief （P＞0.05）. At 0， 2， 6， 12， 24， and 48 hours postoperatively， there were no statistically significant differences in hoarseness scores between the two groups （P＞ 0.05）. The KM curves and Gehan-Breslow test showed no statistically significant difference in the hoarseness relief curves between the two groups （P＞0.05）. The unadjusted Cox model suggested that the pricking-bloodletting group did not significantly promote hoarseness relief [HR=1.38， 95%CI（0.87-2.20）， P＞0.05]. There was no statistically significant difference in the cumulative consumption of Sufentanil between the two groups （Z=-0.90， P＞0.05）. No therapeutic-related adverse events occurred in patients of either group. Conclusion： Pricking-bloodletting at Shaoshang（ LU11） and Shangyang（ LI1） points can rapidly and persistently relieve postoperative sore throat in patients undergoing general anesthesia，and the analgesic effect is independent of age，ASA class，and other related factors. This therapy does not significantly relieve postoperative hoarseness nor affect the cumulative consumption of Sufentanil.