Abstract：The unity of body and spirit concept is the theoretical foundation of Chinese medicine in understanding human life activities. The accelerated decline of ovarian function in women from the age of 35 aligns closely with the description in the Huang Di Nei Jing（ The Yellow Emperor's Inner Classic） that "till thirty-five，the Yangming meridian begins to decline，her face begins to be emaciated and her hair starts to fall." The core lies in the depletion of essence， which leads to the disruption of the dynamic balance of qi， blood， yin， and yang， resulting in bodily decline， impaired mental and spiritual activity， the co-occurrence of somatic and psychological disorders， and ultimately the collapse of both body and spirit. In clinical practice，the principle of simultaneous treatment of body and spirit should be established. Based on the pathogenic root of deficiency，the foundational approach is to replenish essence to consolidate the root，while incorporating methods such as restoring interaction between the heart and the kidney，harmonizing the liver and spleen，coordinating qi dynamics，and harmonizing blood to resolve stasis according to the specific syndrome. Furthermore，attention should be paid to the unity of body and spirit，utilizing not only medicine to supplement bodily deficiencies but also regulating emotions and daily life to settle the spirit， so that essence is restored， spirit is tranquilized，and yin and yang naturally achieve harmony. In doing so，the trend of essence depletion can be curbed， and a harmonious state of body-spirit unity can be reestablished.