Abstract：This paper introduces Professor LI Shunmin′s clinical experience of applying the therapy of reinforcing earth to control water and generate metal for the treatment of uremic pruritus. Uremic pruritus is a common and intractable complication in patients with end-stage renal disease. Based on the theory of correlation among five zangorgans， Professor LI holds that the fundamental pathogenesis of uremic pruritus resides in dysfunction of the lung， spleen， and kidney， which pertains to the syndrome of root deficiency and branch excess. Deficiency of the lung， spleen， and kidney acts as the root cause， while wind-dryness， turbid toxin， and blood stasis serve as branch manifestations. The core therapeutic principle of reinforcing earth to control water and generate metal is established， which takes strengthening the spleen as the pivot， simultaneously restraining water-damp， and nourishing lung qi to harmonize the three zang-organs synchronously. Professor LI creates Shenshuai Prescription，with flexible compatibility of medicines for dispelling wind，discharging turbidity，and invigorating blood to eliminate excess pathogenic factors， by which it can obtain favorable therapeutic effects.