Abstract： Objective： To observe the curative effect of Qidong Yixin Granules combined with Estazolam on cardiac neurosis （CN）. Methods：A total of 100 patients with CN admitted to The People's Hospital of Xinchang from August 2024 to April 2025 were enrolled and divided into the study group and the routine group using the random number table method， with 50 cases in each group. The routine group was treated with Estazolam orally， and the study group was additionally treated with Qidong Yixin Granules based on the treatment in the routine group. The two groups were treated for four weeks. The clinical effects and incidence of adverse reactions，and the changes in traditional Chinese medicine syndrome scores，scores of Hamilton Anxiety Scale （HAMA），Hamilton Depression Scale （HAMD），and Pittsburgh Sleep Quality Index （PSQI），and cardiovascular autonomic nervous function before and after treatment were compared between the two groups. Results：The total effective rate was 96.00% （48/50） in the study group and 82.00% （41/50） in the routine group， the difference being significant （P＜0.05）. After treatment， the traditional Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment （P＜0.05）， and the above scores in the study group were lower than those in the routine group （P＜0.05）. After treatment， the HAMA scores and HAMD scores in the two groups were decreased when compared with those before treatment （P＜0.05），and the above two scores in the study group were lower than those in the routine group （P＜0.05）. After treatment，the PSQI scores in the two groups were decreased when compared with those before treatment （P＜0.05），and the PSQI score in the study group was lower than that in the routine group （P＜0.05）. After treatment， the deep breathing heart rate difference and the standing and lying heart rate difference in the two groups were increased when compared with those before treatment （P＜0.05）， and the deep breathing heart rate difference and the standing and lying heart rate difference in the study group were greater than those in the routine group（ P＜0.05）. The incidence of adverse reactions was 6.00% （3/50） in the study group and 14.00% （7/50） in the routine group. There was no significant difference in the incidence of adverse reactions between the two groups （P＞0.05）. Conclusion：The combination use of Qidong Yixin Granules and Estazolam has a good curative effect on CN， which can effectively regulate the emotion， relieve the symptoms，and improve the cardiovascular autonomic nervous function with high safety.