强骨饮与改良五禽戏联合西药治疗肾虚血瘀型老年女性骨质疏松症临床研究
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R274.9

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浙江省中医药现代化专项项目(2020ZX009);浙江中医药大学2023年附属医院科研专项重点研究项目(2023FSYYZZ19)


Clinical Study of Qianggu Yin and Modified Five-Animal Exercises Combined with Western Medicine in Treating Elderly Female Osteoporosis of Kidney Deficiency and Blood Stasis Type
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    摘要:

    目的:观察在常规西药治疗基础上联合强骨饮与改良五禽戏治疗肾虚血瘀型老年女性骨质疏松症的临床疗效。方法:选取2020年1月—2024年12月在浙江中医药大学附属第二医院诊治的120例肾虚血瘀型老年女性骨质疏松症患者,采取随机数字表法分为对照组与治疗组各60例,最终各54例完成研究。对照组予口服阿法骨化醇软胶囊和碳酸钙D3片治疗,治疗组在对照组基础上联合强骨饮颗粒与改良五禽戏锻炼。2组均治疗12 个月。比较2 组治疗前、治疗6 个月后及12 个月后的步态参数、QCT 腰椎骨密度及视觉模拟评分法(VAS) 评分变化。结果:治疗6个月后,治疗组总路程、平均速度及左、右步幅变异系数较治疗前改善,对照组右步幅变异系数较治疗前改善(P<0.05);治疗12个月后,治疗组总路程、平均速度、左、右步长及左、右步幅变异系数均较治疗前改善(P<0.05),对照组总路程、平均速度及左、右步幅变异系数较治疗前改善(P<0.05),且治疗组左右步长及左右步幅变异系数优于同期对照组(P<0.05)。治疗12个月后,2组QCT腰椎骨密度均较治疗前升高,且治疗组高于对照组(P<0.05)。治疗后,治疗组VAS评分较治疗前降低(P<0.05),2组VAS评分变化趋势存在交互作用(P<0.001)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:强骨饮联合改良五禽戏能够改善老年女性OP患者步态功能,提高腰椎骨密度,减轻骨痛症状,并可能改善跌倒相关功能指标,具有较好的临床应用价值。

    Abstract:

    Abstract: Objective: To observe the clinical efficacy of Qianggu Yin combined with modified Five-Animal Exercises on the basis of conventional western medicine in the treatment of elderly female osteoporosis of kidney deficiency and blood stasis type. Methods:A total of 120 elderly female patients with osteoporosis of kidney deficiency and blood stasis type admitted to the Second Affiliated Hospital of Zhejiang Chinese Medical University from January 2020 to December 2024 were enrolled and randomly divided into a control group and a treatment group using the random number table method,with 60 cases in each group,and finally 54 cases in each group completed the study. The control group was treated with Alfacalcidol Soft Capsules and Calcium Carbonate and Vitamin D3 Tablets,while the treatment group was additionally treated with Qianggu Yin Granules and modified Five-Animal Exercises on the basis of the control group. Both groups were treated for 12 months. The changes in gait parameters,lumbar vertebral bone mineral density( BMD) measured by quantitative computed tomography( QCT),and Visual Analogue Scale( VAS) scores were compared between the two groups before treatment, at 6 months after treatment, and at 12 months after treatment. Results:After 6 months of treatment,the total distance,average speed,and left and right step width coefficients of variation in the treatment group all improved compared with those before treatment,and the right step width coefficient of variation in the control group improved compared with that before treatment (P<0.05). After 12 months of treatment, the total distance,average speed,left and right step length,and left and right step width coefficients of variation in the treatment group all improved compared with those before treatment (P<0.05),and the total distance,average speed, and left and right step width coefficients of variation in the control group improved compared with those before treatment (P<0.05), and the left and right step length and left and right step width coefficients of variation in the treatment group were superior to those in the control group at the same time point (P<0.05). After 12 months of treatment,the QCT results showed that the lumbar BMD in both groups increased compared with that before treatment, and the BMD in the treatment group was higher than that in the control group (P<0.05). After treatment, the VAS score in the treatment group decreased compared with that before treatment (P<0.05), and there was a significant interaction effect between groups over time for VAS score change (P<0.001). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Qianggu Yin combined with modified Five-Animal Exercises can improve gait function,increase lumbar BMD,alleviate bone pain, and may improve fall-related functional indicators in elderly female patients with osteoporosis, showing favorable clinical application value.

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肖蔚林,赵岩,袁一峰,史晓林,赵云珍.强骨饮与改良五禽戏联合西药治疗肾虚血瘀型老年女性骨质疏松症临床研究[J].新中医,2026,58(19):20-25

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  • 在线发布日期: 2026-10-16
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