Abstract： Objective： To observe the clinical effect of Shuxin Jieyu acupuncture （a needling technique for soothing the heart and relieving depression） combined with mild-warm moxibustion in the treatment of cardiac neurosis （CN） of liver depression and qi stagnation type. Methods：A total of 74 patients with CN of liver depression and qi stagnation type， recruited from the Center for Preventive Treatment of Disease at Shenzhen Bao'an Traditional Chinese Medicine Hospital （Group） and via online enrollment between January 2025 and June 2025， were included and randomly assigned using a random number table method to a control group and an observation group，with 37 cases in each group. Due to participant dropout，36 cases in each group ultimately completed the treatment. The control group received conventional treatment with Metoprolol Tartrate Tablets and Oryzanol Tablets. Based on the conventional treatment， the observation group additionally received Shuxin Jieyu acupuncture combined with mild-warm moxibustion. Both groups were treated continuously for 2 courses. Before treatment，after treatment，and 1 month after treatment，traditional Chinese medicine （TCM） syndrome scores，Hamilton Anxiety Scale （HAMA） scores，Hamilton Depression Scale （HAMD） scores， and Somatic Self-Rating Scale （SSS） scores were assessed in both groups. The clinical effect was compared，and adverse reactions were observed. Results：The scores of TCM syndrome，HAMA， HAMD，and SSS at the three time points showed statistically significant differences overall between the two groups （P＜ 0.05）. The scores of TCM syndrome， HAMA， HAMD， and SSS showed a declining trend over time in both groups. After treatment and 1 month after treatment，the scores of TCM syndrome，HAMA，HAMD，and SSS were decreased when compared with baseline in both groups （P＜0.05）；the scores of TCM syndrome，HAMA，HAMD，and SSS 1 month after treatment were lower than those after treatment in both groups （P＜0.05）. After treatment and 1 month after treatment，the observation group had lower scores of TCM syndrome，HAMA，HAMD，and SSS than the control group at the same time point （P＜0.05）. The total effective rate of TCM syndrome effect in the observation group was 94.44% （34/36）， higher than that of 72.22% （26/36） in the control group （P＜0.05）. The total effective rates for anxiety and depression in the observation group were 91.67% （33/36） and 88.89% （32/36），respectively，both higher than those of 66.67% （24/36） and 69.44% （25/36） in the control group （P＜0.05）. No serious adverse reactions occurred in either group during treatment. Conclusion： Shuxin Jieyu acupuncture combined with mild-warm moxibustion can effectively improve TCM syndromes，alleviate anxiety，depression，and somatic symptoms in patients with CN of liver depression and qi stagnation type， enhance clinical effect， and demonstrate favorable safety and application value.