Abstract： By summarizing the studies on the regulation of sirtuin 1 （SIRT1）-related signaling pathways by Chinese medicine monomers and compounds， this article reviews the mechanisms through which SIRT1-related signaling pathways mediate the effects of Chinese medicine monomers and compounds in promoting wound healing in diabetic foot ulcers. Reduced SIRT1 activity may lead to persistent inflammatory reactions，redox imbalance，impaired autophagy，and angiogenesis disorders. Chinese medicine monomers including saponins，alkaloids，flavonoids，and polysaccharides， as well as various Chinese medicine compounds， may exert anti-inflammatory， antioxidant， proangiogenic， and tissue remodeling effects through signaling pathways such as SIRT1/nuclear factor-κB （NF-κB）， SIRT1/nuclear factor erythroid 2-related factor 2 （Nrf2）/heme oxygenase-1 （HO-1）， AMP-activated protein kinase（ AMPK）/SIRT1/forkhead box protein O1（ FoxO1），microRNA（ miRNA）/SIRT1，and SIRT1/autophagy. SIRT1 is an important target for Chinese medicine in promoting diabetic foot ulcer wound repair. However，current evidence is predominantly derived from cellular and animal experiments， and high-quality clinical studies are still needed for further validation.