Abstract： Precancerous lesions of gastric cancer （PLGC） refer to histopathological alterations of the gastric mucosa with a tendency toward malignant transformation，and represent a critical stage in the progression from normal gastric mucosa to gastric cancer that holds potential for intervention and reversal. Healthy qi deficiency with latent toxin constitutes the core pathogenesis throughout the development and progression of PLGC. Healthy qi deficiency serves as the foundation for disease onset， latent toxin accumulation represents the central link in disease progression， the interbinding of toxin and stasis acts as the driving factor for disease advancement，and ultimately，healthy qi exhaustion with malignant transformation marks the terminal outcome. The treating disease before it arises concept，originating from the Huang Di Nei Jing （The Yellow Emperor's Inner Classic）， is a core principle in traditional Chinese medicine for disease prevention and treatment，and holds significant clinical guiding value for the management of PLGC. Based on the healthy qi deficiency with latent toxin theory， this article explores the specific application of the treating disease before it arises concept in the prevention and treatment of PLGC from three aspects："preventing disease before onset and intervening before disease initiation； preventing progression once disease has developed and curtailing disease advancement； and preventing recurrence after recovery and integrating nourishment into treatment."