Abstract：Thyroid nodules（ TN） represent one of the most common thyroid disorders. The trinity life view of formqi- spirit elucidates the dynamic and coordinated relationship among form，qi，and spirit in the human body. Drawing upon this theory，the authors propose that the core pathogenesis of TN lies in the disharmony of form，qi，and spirit. Its onset and progression can be delineated into three stages： "spirit failing to maintain inner tranquility， qi movement becoming deranged， and form-substance condensing into nodules. " Accordingly， the fundamental therapeutic principle is established as "regulating the spirit as the root，rectifying qi as the core，and dissolving form-substance as an adjunct." Specifically， spirit regulation is achieved through mind-calming herbal formulas， emotional therapy， acupuncture and moxibustion，and mind-body exercises；qi rectification involves soothing the liver and regulating qi with herbal formulas，acupuncture and moxibustion，and external applications to restore the functional pivot and cut off the source of phlegm and stasis formation；and form-substance dissolution employs softening hardness and dissipating masses，as well as activating blood and dissolving stasis，to resolve already-formed nodules. This article aims to provide new diagnostic and therapeutic insights for the traditional Chinese medicine-based prevention and treatment of TN.