Abstract： Knee osteoarthritis （KOA） comorbid with depression is a common chronic psychosomatic disease in clinical practice. Based on the theory of yin-yang，water-fire，and qi-blood，Professor LIN Chuangjian proposes that the root cause of KOA comorbid with depression lies in the deficiency of the spleen and stomach as well as the failure in qi transformation，its development is driven by the stagnation in the middle energizer and qi stagnation with blood stasis， and its manifestation is characterized by phlegm blended with blood stasis and depression transforming into fire. In view of the distinct pathological stages mentioned above，Professor LIN has respectively developed Shengyang Chubi Huayu Prescription for warming yang and invigorating the spleen， and resolving dampness and promoting qi circulation； Tiaoshu Tongbi Chuyu Prescription for activating qi and blood circulation，circulation，and unblocking collaterals and relieving pain， and Dizhuo Tongbi Chuyu Prescription for eliminating phlegm， expelling blood stasis， and clearing stagnated heat. He systematically constructs a theoretical framework of principles，methods，formulas，and medicinals for treating KOA comorbid with depression based on the theory of yin-yang，water-fire，and qi-blood.