基于数据挖掘分析儿童矮小症中医证型及用药规律
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R272;R725.8

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江西省卫生健康委科技创新联合项目(2025L3036);江西省教育厅科学技术研究项目(GJJ2403625);江西省中医药管理局科技计划项目(2023A0034);江西省双高人才项目(12623009);江西省(省直单位) 名老中医药专家学术经验继承工作项目(赣财社指〔2022〕81号);江西中医药大学大学生创新创业训练项目(202510412233)


Analysis of Traditional Chinese Medicine Syndrome Types and Medication Rules for Pediatric Short Stature Based on Data Mining
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    目的:通过数据挖掘分析儿童矮小症中医核心证型、中药用药规律,整合优化其中医诊疗方案。方法:检索中国知网、万方、维普数据库自建库至2025年3月30日的相关文献,筛选中药内服治疗儿童矮小症的临床研究文献,规范证型与中药名称后,借助Excel 统计频次,Origin 2024 分析高频药物聚类,SPSSModeler、Cytoscape分析关联规则。结果:共提取107首处方,涉及117味中药,用药总频次1 185次,中医证型以脾肾两虚(63.04%)、脾虚(18.48%) 为主;用药频次≥15次的中药21味,频次排名前3的中药为茯苓、白术、甘草,药性以温、寒居多,药味以甘、苦、辛为核心,归经以肾、脾、肝经为主,功效以补虚药为主。关联规则得到茯苓、白术、山药、甘草为核心药物,聚类获得5组处方。结论:儿童矮小症多因脾运失司,肾元失充,肝筋失濡所致,治疗需标本兼治,脾肾肝三脏同调,以健脾助长为根本,根据证候辨证以健脾和胃、健脾补肾、健脾疏肝等为具体治则。常采用补虚、清热、理气药,临床可用四君子汤、补肾地黄丸、异功散等方加减治疗。

    Abstract:

    Abstract:Objective:To analyze the core traditional Chinese medicine (TCM) syndrome types and medication rules for pediatric short stature through data mining, and to integrate and optimize the TCM diagnosis and treatment plan. Methods:Relevant literature published from database inception to March 30,2025 was retrieved from CNKI, Wanfang, and VIP databases. Clinical studies on oral administration of Chinese herbal medicines for pediatric short stature were screened. After standardizing syndrome types and names of Chinese herbal medicines,frequency statistics were performed using Excel, cluster analysis of high-frequency medicines was conducted using Origin 2024, and association rule analysis was carried out using SPSS Modeler and Cytoscape. Results:A total of 107 prescriptions were extracted,involving 117 Chinese herbal medicines with a total medication frequency of 1 185. The predominant TCM syndrome types were spleen-kidney deficiency (63.04%) and spleen deficiency (18.48%). Twenty-one Chinese herbal medicines had a frequency≥15, with the top three being Poria, Atractylodis Macrocephalae Rhizoma, and Glycyrrhizae Radix et Rhizoma. Medicinal properties were mostly warm and cold; flavors were mainly sweet, bitter, and acrid; channel entry was predominantly kidney, spleen, and liver meridians; and efficacy was dominated by deficiency-supplementing. Association rule analysis identified Poria, Atractylodis Macrocephalae Rhizoma, Dioscoreae Rhizoma, and Glycyrrhizae Radix et Rhizoma as core medicines, and five prescription clusters were obtained. Conclusion:Pediatric short stature is mostly attributed to dysfunction of spleen transportation,insufficiency of kidney essence, and malnutrition of liver sinews. Treatment should address both root and branch, regulate the spleen, kidney, and liver simultaneously, and adopt strengthening the spleen to promote growth as the fundamental principle. Based on syndrome differentiation, specific therapeutic methods include strengthening the spleen and harmonizing the stomach, strengthening the spleen and supplementing the kidney, and strengthening the spleen and soothing the liver. Commonly used Chinese herbal medicines are deficiency-supplementing medicines, heat-clearing medicines,and qi-regulating medicines. Modified Sijunzi Decoction,Bushen Dihuang Pills,and Yigong Powder may be applied clinically.

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易惺钱,熊智燚,刘英,王立,李金娥,李小艳,董思佳,陈晓凡.基于数据挖掘分析儿童矮小症中医证型及用药规律[J].新中医,2026,58(19):197-204

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  • 在线发布日期: 2026-10-16
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