Abstract： Objective： To analyze the key components， core targets， and potential molecular mechanisms of Qushi Sanpian Zhitong Decoction in treating migraine based on network pharmacology and molecular docking technology.Methods： Active ingredients， corresponding targets， and migraine-related targets of Qushi Sanpian Zhitong Decoction were obtained by searching relevant databases and reviewing literature. Intersecting targets between drugs and disease were imported into the STRING 12.0 database to construct a PPI network and screen core targets. Gene Ontology （GO） functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes （KEGG） pathway enrichment analysis were performed using the DAVID platform. A "drug-component-intersecting target-disease" network was constructed using Cytoscape software to screen key components. The key components were validated using the ENA database. Molecular docking and visualization of core targets and key components were performed using AutoDock and PyMOL software. Results ： A total of 178 components of Qushi Sanpian Zhitong Decoction were screened， corresponding to 1 002 targets. There were 1 331 disease targets， with 207 intersecting targets between drugs and disease. Five key components were identified： sitosterol， kaempferol， quercetin， β-sitosterol， and stigmasterol. Five core targets were identified：AKT serine/threonine kinase 1 （AKT1），tumor necrosis factor （TNF）， interleukin-1β（ IL-1β），signal transducer and activator of transcription 3（ STAT3），and prostaglandin-endoperoxide synthase 2 （PTGS2）. The GO functional enrichment analysis showed that potential targets of Qushi Sanpian Zhitong Decoction in intervening in migraine were mainly localized to cellular structures such as plasma membrane，synapse， and dendrites. In terms of molecular function， they were enriched in G protein-coupled serotonin receptor activity， neurotransmitter receptor activity，and identical protein binding，and involved in biological processes such as cellular response to external stimuli， chemical synaptic transmission， G protein-coupled receptor-cyclic nucleotide second messenger signaling， and positive regulation of membrane calcium ion levels. The KEGG analysis primarily involved neuroactive ligand-receptor interaction signaling pathway， calcium signaling pathway， and advanced glycation end products-receptor for advanced glycation end products （AGE-RAGE） signaling pathway in diabetic complications. Molecular docking results showed that the key components exhibited good binding affinity with the core targets. Conclusion： Qushi Sanpian Zhitong Decoction may act on targets centered on AKT1， IL-1β， and PTGS2 through signaling pathways such as neuroactive ligand-receptor interaction，calcium，and AGE-RAGE，exerting antioxidant and anti-inflammatory effects，thereby intervening in migraine.