190 例慢性心力衰竭急性加重期患者中医证候分布规律研究
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R256.2

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四川省科技计划重点研发项目(2022YFS0410);四川省中医药管理局科学技术研究专项课题(2024MS609);南充市应用基础和技术 研究专项项目(25YYJCYJ0049)


Study on Distribution Patterns of Traditional Chinese Medicine Syndrome Types in 190 Patients with Acute Exacerbation of Chronic Heart Failure
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    摘要:

    目的:基于传统本虚标实证候要素和三焦壅滞证候要素分析慢性心力衰竭(CHF) 急性加重期的中医证候特征及分布规律。方法:纳入190例CHF急性加重期患者,收集中医证候诊断所需信息及相关临床资料,统计单个证素、证素组合的频次,采用两步聚类法探讨主要中医证型的分布。结果:①190例CHF急性加重期患者中8个本虚标实证素以宗气亏虚、血瘀、元气亏虚最为多见。大多数患者存在不同程度的三焦壅滞,其中上焦壅滞最多。②本虚与病理因素证素数量组合:同时具有5 证素和6 证素的患者最为常见,分别占35.8%和26.8%;本虚与三焦壅滞证素数量组合:以4证素和5证素组合最为常见,均占27.4%。③患者以虚实夹杂证为主,纯虚证和纯实证较少。④本虚与病理因素证素共出现54 种证素组合,通过两步聚类可分为7 类,7类患者均见元气亏虚、宗气亏虚,其中有6类均见血瘀、有6类均见水饮、有5类均见痰浊;本虚与三焦壅滞证素共出现32种证素组合,通过两步聚类可分为4类,4类患者均见宗气亏虚、上焦壅滞,其中有3类均见元气亏虚。结论:CHF急性加重期的主要病机以宗气亏虚和(或) 元气亏虚为本,以血瘀、痰浊、水饮为标,病理因素又以壅滞上焦为主。CHF急性加重期的基本证型为宗元亏虚、邪壅焦滞,简称气虚焦滞证,可分为宗元亏虚、邪壅焦滞,气阴两虚、邪壅焦滞,气阳亏虚、邪壅焦滞,宗元亏虚、焦滞热郁4个证型。

    Abstract:

    Abstract: Objective: To analyze the characteristics and distribution patterns of traditional Chinese medicine syndrome types in patients with acute exacerbation of chronic heart failure (CHF) based on both conventional basic syndrome elements of deficiency in root and excess in branch as well as triple-energizer stagnation. Methods:A total of 190 patients with acute exacerbation of CHF were enrolled. Information required for traditional Chinese medicine syndrome diagnosis and relevant clinical data were collected. Frequencies of individual syndrome elements and their combinations were calculated. Two-step cluster analysis was employed to explore the distribution of major traditional Chinese medicine syndrome types. Results:① Among the eight basic syndrome elements identified in the 190 patients, pectoral qi deficiency, blood stasis, and primordial qi deficiency were the most prevalent. The majority of patients presented with varying degrees of triple energizer stagnation, among which upper energizer stagnation was the most common. ② Regarding the combination of deficiency-root and pathological factor syndrome elements,the coexistence of five and six syndrome elements was the most frequent, accounting for 35.8% and 26.8%, respectively. For the combination of deficiency-root and triple energizer stagnation syndrome elements, the coexistence of four and five syndrome elements was the most common, each accounting for 27.4%. ③ The predominant syndrome type was intermingled deficiency-excess , with pure deficiency and pure excess types being relatively rare. ④A total of 54 combinations of deficiency-root and pathological factor syndrome elements were identified, which were classified into seven clusters by two-step clustering. All seven clusters featured primordial qi deficiency and/or pectoral qi deficiency; among them, six clusters included blood stasis, six included fluid retention, and five included phlegm turbidity. A total of 32 combinations of deficiency-root and triple energizer stagnation syndrome elements were identified, which were classified into four clusters by two-step clustering. All four clusters featured pectoral qi deficiency and upper energizer stagnation,and three of them included primordial qi deficiency. Conclusion:The core pathogenesis of acute exacerbation of CHF is rooted in pectoral qi deficiency and/or primordial qi deficiency,with blood stasis,phlegm turbidity,and fluid retention as the superficial manifestations,and pathological factors predominantly stagnating in the upper energizer. The basic syndrome type of acute exacerbation of CHF is pectoral-primordial qi deficiency with pathogen stagnation in the energizers,abbreviated as qi deficiency with energizer stagnation syndrome. This can be further classified into four subtypes: pectoral-primordial qi deficiency with pathogen stagnation in the energizers;deficiency of qi and yin with pathogen stagnation in the energizers;deficiency of qi and yang with pathogen stagnation in the energizers;and pectoral-primordial qi deficiency with energizer stagnation and heat depression.

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杜峣楠,郭淦文,唐卷壹,徐仕宏,杨莹洁,王晓峰.190 例慢性心力衰竭急性加重期患者中医证候分布规律研究[J].新中医,2026,58(20):1-9

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  • 在线发布日期: 2026-10-21
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