Abstract： Objective： To explore the relationship between traditional Chinese medicine constitution types and quality of life in patients with polycystic ovary syndrome （PCOS）， and to analyze the risk factors for PCOS onset. Methods： A total of 89 PCOS patients attending the gynecology outpatient clinic of The First Affiliated Hospital of Guangzhou University of Chinese Medicine from October 2023 to March 2024 were selected as the PCOS group. Concurrently， 45 healthy women attending the physical examination centers of The First Affiliated Hospital of Guangzhou University of Chinese Medicine and Guangzhou Tianhe Hospital of Traditional Chinese Medicine were selected as the healthy group. Clinical characteristics and quality of life were compared among PCOS patients with different traditional Chinese medicine constitution types，and binary logistic regression analysis was used to identify the risk factors. Results： Among the PCOS group， the highest proportion was patients with damp-heat constitution （25.84%），followed by qi deficiency constitution （16.85%）. Patients with phlegm-damp constitution had higher body mass index（ BMI） and waist-to-hip ratio（ WHR） than those with blood stasis，yang deficiency，and qi deficiency constitutions （P＜0.05）. Frequent consumption of sweet foods （including beverages）， frequent use of plastic tableware or cups， frequent exposure to kitchen fumes （≥4 days per week）， high life stress， low mood/ irritability，and a parental history of overweight or obesity were identified as risk factors for PCOS （P＜0.05），while having an exercise habit was a protective factor （P＜0.05）. The Modified Polycystic Ovary Syndrome Quality of Life Questionnaire （MPCOSQ） scores in the PCOS group were lower than those in the healthy group （P＜0.05）. The MPCOSQ scores of patients with qi stagnation constitution were lower than those of yang deficiency and balanced constitutions （P＜0.05），and scores of yin deficiency constitution were lower than those of balanced constitution （P＜ 0.05）. Conclusion：The onset of PCOS is closely associated with damp-heat and phlegm-damp constitutions，with the latter showing significant metabolic abnormalities. Frequent consumption of sweets and beverages， plastic exposure， kitchen fumes，psychological stress，and parental obesity are independent risk factors for PCOS，while exercise serves as a protective factor. PCOS patients with qi stagnation constitution have the lowest quality of life scores，necessitating targeted psychological interventions.