Abstract：Based on a review of ancient medical texts regarding acupuncture point sequencing and relevant modern research， this article analyzes the theoretical basis and clinical application of acupuncture point sequencing from two dimensions：point specificity and disease diversity. The selection of acupuncture point sequence may be determined by integrating considerations of both point specificity and disease diversity， taking into account factors such as disease etiology，location，nature，and progression，so as to rationally establish the intervention order of points and optimize the synergistic effect of point combinations. This paper aims to provide a reference for the clinical application of acupuncture point sequencing and related research.