Abstract：Objective：To observe the clinical efficacy of acupuncture combined with Chinese medicine package in the treatment of cervical spondylotic radiculopathy （CSR） with wind-cold obstructing collateral syndrome. Methods： A total of 135 patients with CSR of wind-cold obstructing collateral type admitted to the First Affiliated Hospital of Henan University of Chinese Medicine from January 2024 to February 2025 were enrolled. They were randomly divided into three groups， with 45 cases in each group. Group A received Chinese medicine package treatment， group B received acupuncture treatment， and group C received acupuncture combined with Chinese medicine package treatment. The clinical efficacy， Neck Disability Index （NDI）， McGill Pain Questionnaire score， Tanaka-Yasuhisa Cervical Spondylosis Symptom Scale （YT20SS） score，wind-cold obstructing collateral syndrome score，cervical range of motion， cerebral arterial hemorheology （mean blood flow velocity and resistance index of the basilar artery and vertebral arteries），inflammatory factors [tumor necrosis factor-α （TNF-α），interleukin-1β （IL-1β），interleukin- 6 （IL-6）]， calcitonin gene-related peptide （CGRP）， and T lymphocyte subsets （CD3+ level， CD4+ level， CD8+ level，and CD4+/CD8+ ratio） were compared among the three groups. Results：After treatment，the NDI，McGill Pain Questionnaire score，wind-cold obstructing collateral syndrome score，resistance index of blood flow，and the levels of TNF- α， IL-1β， IL-6， CGRP， and CD8+ in all groups decreased significantly compared with those before treatment （P＜0.05）；while the YT20SS score，cervical range of motion，mean blood flow velocity，levels of CD3+ and CD4+，and CD4+/CD8+ ratio increased significantly （P＜0.05）. Moreover，the differences in all indicators between group C and group A， as well as between group C and group B， were statistically significant （P＜0.05）. The total clinical effective rate was 80.95% （34/42） in group A， 76.74% （33/43） in group B， and the effective rate of 97.67%（ 42/43） in group C was significantly higher than that in both group A and group B（ P＜0.05）. At the six-month follow-up，the recurrence rates were 38.24% （13/34） in group A，45.45% （15/33） in group B，and 4.76% （2/42） in group C， with group C showing a significantly lower recurrence rate than both group A and group B （P＜0.05）. Conclusion：Acupuncture combined with Chinese medicine package can improve cervical range of motion and alleviate cervical pain in patients with CSR of wind-cold obstructing collateral syndrome. Its mechanism may be related to improving cerebral arterial hemorheology and regulating immune-inflammatory responses.