Abstract： Objective： To observe the effect of acupoint catgut embedding therapy on reducing weight of overweight/obesity patients complicated with insulin resistance and its effect on glucose metabolism and blood lipid level. Methods： A total of 64 overweight/obesity patients with insulin resistance diagnosed and treated in Huzhou Wuxing Hospital of Chinese Medicine from June 2024 to October 2025 were collected retrospectively as the study subjects. According to the treatment methods，they were divided into the treatment group and the control group，with 32 cases in each group. The treatment group was treated with acupoint catgut embedding therapy and Metformin and the control group was given Metformin. The body mass index （BMI）， the levels of lipid metabolism indexes [triglyceride （TG），total cholesterol （TC）， low density lipoprotein cholesterol （LDL-C）] and glucose metabolism related indexes [fasting plasma glucose （FPG），fasting insulin （FINS），Homeostasis Model Assessment of Insulin Resistance （HOMA-IR）] before and after treatment were compared between the two groups. Results：After treatment，the BMI in both groups was decreased when compared with that before treatment （P＜0.05），and the BMI in the treatment group was lower than that in the control group （P＜0.05）. After treatment，the levels of TC，TG，and LDL-C in both groups were reduced when compared with those before treatment （P＜0.05），and the above three levels in the treatment group were lower than those in the control group （P＜0.05）. After treatment，the levels of FPG，FINS，and HOMA-IR in both groups were decreased when compared with those before treatment （P＜0.05）， and the above three levels in the treatment group were lower than those in the control group （P＜0.05）. Conclusion：The combined use of "belt vessel regulating" catgut embedding therapy and Metformin can reduce the BMI of overweight/obesity patients complicated with insulin resistance，and improve their glucose metabolism.