Abstract： Patients with acute myocardial infarction （AMI） often experience insomnia after undergoing percutaneous coronary intervention（ PCI），which affects patients' prognosis and quality of life. Guided by the treatment principle of "Qu Yu Chen Cuo" （Removing old and stagnant pathogens）， this study proposes the simultaneous application of three methods， including regulating liver and soothing qi， regulating middle energizer and resolving phlegm，and promoting yang qi to resolve blood stasis，with flexible adjustments according to the predominance of qi， phlegm or blood stasis. The strategy aims to smooth qi flow，resolve phlegm，dissipate blood stasis，thus harmonizing the body and spirit. Through systematic analysis of the pathogenesis evolution and key treatment points， a treatment framework integrating principle and method is established. It highlights the holistic spirit-regulating and clinical syndrome differentiation of traditional Chinese medicine，so as to provide reference for the traditional Chinese medicine diagnosis and treatment of insomnia after PCI.