Abstract：Professor WANG Qingguo，a Chinese medicine master，proposes that the pathogenesis of climacteric syndrome is rooted in kidney essence deficiency， with liver failing to maintain free flow of qi and dysfunction of the cardinal axis as triggering factors， and disharmony between nutrient and defensive qi along with restlessness of heart spirit as key links， eventually leading to imbalance of yin and yang， intermingled deficiency and excess， and disharmony among multiple zang-organs. His treatment adheres to the academic thought of "unblocking and balancing to achieve harmony". Clinically，he adopts tonifying and unblocking methods as the core，supplemented by clearing and purging，and applies four therapeutic strategies：nourishing kidney essence to harmonize yin and yang；soothing the liver and regulating the cardinal axis to smooth qi movement； harmonizing nutrient and defensive qi and calming the heart to settle the spirit； and addressing both deficiency and excess to harmonize multiple zang-organs. He skillfully uses modified classical formulas， employing Rehmanniae Radix Praeparata， Corni Fructus， and Lycii Fructus to replenish kidney essence and consolidate the constitution；Anemarrhenae Rhizoma and Phellodendri Chinensis Cortex to clear and purge deficient fire；Os Draconis，Ostreae Concha，and Tritici Levis Fructus to subdue yang and arrest sweating； and Bupleuri Radix and Scutellariae Radix to soothe the Shaoyang cardinal axis. By simultaneously strengthening healthy qi， removing stagnation， and clearing pathogenic heat， he restores the body to a harmonious state where yin is balanced and yang is secured，thus achieving good clinical effect.