Abstract：This article introduces the clinical experience of chief physician WANG Wenrui's clinical experience in treating depression. In the view of chief physician WANG Wenrui， the pathogenesis of depression is attributed to the dysfunction and mutual influence of the three pivots，specifically characterized by "failure of the liver pivot in ensuring the free flow of qi， the kidney pivot in storing essence， and the middle pivot in mediating qi movement." He has proposed the therapeutic approach of simultaneous regulation of the three pivots， which encompasses "smoothing the liver pivot，replenishing the kidney pivot，and mediating the middle pivot," with a particular emphasis on restoring the pivotal movement of the middle earth. In clinical practice，he achieves considerable therapeutic efficacy through precise syndrome differentiation，skillful use of herb pairs，and simultaneous regulation of both the body and mind.