Abstract： This article introduces the clinical experience of Professor YANG Zejin in treating postmenopausal osteoporosis under the guidance of the deficiency-stasis-toxin theory. In the view of Professor YANG Zejin， the pathogenesis of postmenopausal osteoporosis is attributed to the following cascade： "deficiency of kidney essence and gradual decline of qi and blood lead to blood stasis obstruction，which in turn brings about pain；when stasis persists， toxic pathogen erodes the bone，and without timely intervention，the condition will worsen and cause further physical deterioration." Accordingly，he proposes the differentiation and treatment of postmenopausal osteoporosis based on the deficiency-stasis-toxin theory. Guided by the principle of staging-based syndrome differentiation and treatment， he emphasizes identifying the weighted relationships among deficiency， stasis， and toxin at different stages. This is primarily reflected in the therapeutic principle of "tonifying deficiency as the foundation，with simultaneous regulation of both deficiency and excess，" while integrating the patient's individual constitution and the different stages of disease progression to accurately grasp the core pathogenesis throughout the course of postmenopausal osteoporosis. In terms of treatment，he takes tonifying deficiency and strengthening bone as the root，and removing stasis and resolving toxin as the branch， so as to prevent marrow depletion leading to bone atrophy. He emphasizes precise staging-based pathogenesis identification to achieve the best possible therapeutic outcome.